Weiss · Proceedings of the National Academy of Sciences of the United States of America 2012 · comparative cross-sectional observational study · n=508

Evidence for a midlife crisis in great apes consistent with the U-shape in human well-being.

Level 5 - mechanism / opinion, no new human data

Animal research studying subjective well-being across the lifespan in non-human primates.

PubMed 23169637 · doi:10.1073/pnas.1212592109 · record verified 2026-08-26

What was done

Researchers evaluated the lifespan trajectory of well-being in 508 great apes across three distinct cohorts (two samples of chimpanzees and one sample of orangutans). Individual ape well-being was assessed using standardized reports completed by human raters familiar with each animal. The relationship between age and well-being was analyzed using both parametric and non-parametric statistical methods.

What was found

The abstract reports no exact numerical values, effect sizes, or confidence intervals. It reports that well-being in chimpanzees and orangutans followed a U-shaped curve across age—starting higher in youth, reaching a minimum in midlife, and rising again in older age—consistent with patterns documented in human populations.

Why it matters

These findings suggest that the midlife nadir in well-being observed in humans is not solely driven by modern human socioeconomic institutions, culture, or societal structures, but may have evolutionary and biological underpinnings shared with other great apes.

Limits

The study relies on proxy assessments of ape well-being scored by human observers rather than direct internal subjective reports. The abstract does not provide exact point estimates, inflection ages, or effect sizes. Generalizability to human psychological phenomena remains an indirect evolutionary parallel rather than direct human evidence.

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