Obsessive-compulsive disorder: an integrative genetic and neurobiological perspective.
Level 5 - mechanism / opinion, no new human data
Narrative review synthesizing genetic, neuroimaging, and clinical mechanisms without systematic review methodology
PubMed 24840803 · doi:10.1038/nrn3746
What was done
This narrative review synthesized evidence from family, twin, neuroimaging, neuropsychological, and genetic investigations to describe an integrative pathophysiological model of obsessive-compulsive disorder (OCD).
What was found
The abstract reports no numerical data or quantitative effect sizes. It summarizes that OCD involves dysfunction of the cortico-striato-thalamo-cortical (CSTC) circuit alongside executive function impairments, with polygenic influences on serotonergic, dopaminergic, and glutamatergic transmission interacting with environmental triggers (such as perinatal adversity, psychological trauma, and neurological trauma).
Why it matters
It provides an integrative conceptual framework linking molecular genetics, neurotransmitter systems, and neural circuit dysfunction to explain how environmental risk factors manifest as OCD phenotypes.
Limits
The abstract reports no primary data, systematic search protocol, or quantitative estimates. Specific gene variants, effect sizes, and underlying study populations are not specified in the abstract.