The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer.
Level 5 - mechanism / opinion, no new human data
Tool development and retrospective re-analysis of previously published mouse and human data.
PubMed 25798181 · doi:10.1186/s12986-015-0009-2
What was done
The authors developed the Glucose Ketone Index Calculator (GKIC) to track the ratio of blood glucose to ketones (beta-hydroxybutyrate) as a single metric (Glucose Ketone Index, GKI). They applied this calculator to previously published data on blood glucose and ketone levels from humans and mice with brain tumors undergoing ketogenic diets or calorie restriction.
What was found
The authors reported a clear relationship between the GKI and therapeutic efficacy using ketogenic diets and calorie restriction. However, the abstract provides no specific numbers, sample sizes, cutoffs, or statistical values.
Why it matters
The paper introduces the GKI as a standardized composite ratio to help monitor metabolic therapy in brain cancer research and clinical practice.
Limits
No quantitative data, sample sizes, or effect estimates are reported in the abstract. The calculation was validated against previously published mouse and human datasets rather than a prospective clinical trial.
Cited by
- partial The Glucose Ketone Index can be used as a clinical tool to monitor and manage all major chronic diseases and cancers.