Szymusiak · Handbook of clinical neurology 2018 · narrative review · n=?

Body temperature and sleep.

Level 5 - mechanism / opinion, no new human data

Narrative review synthesizing physiological and mechanistic pathways with no new human trial or empirical data

PubMed 30454599 · doi:10.1016/B978-0-444-63912-7.00020-5 · record verified 2026-08-26

What was done

This narrative review summarizes mammalian and human physiological literature on the coupling between circadian rhythms, sleep-wake states, and body temperature regulation, highlighting autonomic, thermoeffector, and hypothalamic pathways.

What was found

The abstract reports no numerical data or effect sizes. It describes established physiological mechanisms: core body temperature decreases during sleep due to behavioral quiescence, reduced muscle tone, and autonomic changes; peripheral vasodilation leads to increased distal skin temperature facilitating heat loss at sleep onset; thermoregulatory defense mechanisms differ between NREM and REM sleep; and warm-sensitive neurons in the preoptic/anterior hypothalamus exhibit spontaneous activation during sleep onset and NREM sleep compared with wakefulness.

Why it matters

It outlines the neurobiological and autonomic architecture integrating sleep regulation with thermoregulatory control, explaining the physiology of distal heat shedding during sleep onset.

Limits

As a narrative review, it presents no original empirical data, quantitative metrics, or systematic search methodology. Specific human sample characteristics, environmental conditions, and clinical implications are not detailed in the abstract.

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