Horigome · Psychological medicine 2020 · systematic review and meta-analysis · n=703 participants across 22 studies

Virtual reality exposure therapy for social anxiety disorder: a systematic review and meta-analysis.

Level 1 - systematic review of randomized trials

Systematic review and meta-analysis of clinical intervention studies

PubMed 33070784 · doi:10.1017/S0033291720003785 · record verified 2026-08-26

What was done

Authors conducted a PROSPERO-registered systematic review and meta-analysis of studies evaluating virtual reality exposure therapy (VRET) for social anxiety disorder (SAD) or related phobias. Eligible studies had at least three VRET sessions and a minimum of 10 participants. The primary outcome was change in social anxiety scores (random-effects Hedges' g); the secondary outcome was the risk ratio for treatment discontinuation.

What was found

Twenty-two studies (n = 703) were analyzed. VRET significantly reduced social anxiety scores at post-intervention (Hedges' g = -0.86, 95% CI -1.04 to -0.68), 3 months (-1.03, 95% CI -1.35 to -0.72), 6 months (-1.14, 95% CI -1.39 to -0.89), and 12 months (-0.74, 95% CI -1.05 to -0.43). Compared to in vivo exposure, VRET had similar post-intervention efficacy and dropout rates, but became inferior at longer follow-up points (exact comparative statistics not provided in abstract).

Why it matters

This confirms VRET is an effective, acceptable alternative to traditional in vivo exposure for SAD, though clinical durability may lag behind real-world exposure over time.

Limits

The overall sample size across 22 trials is relatively small (average ~32 participants per study), and the abstract does not report specific effect sizes, confidence intervals, or p-values for the comparative analysis against in vivo exposure.

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