International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function.
Level 5 - mechanism / opinion, no new human data
Narrative review and expert consensus nomenclature report
PubMed 33370241 · doi:10.1124/pr.118.015552
What was done
This International Union of Basic and Clinical Pharmacology (IUPHAR) review synthesized the structural diversity, pharmacological profiles, physiological roles, and therapeutic applications across the 14 5-hydroxytryptamine (5-HT) receptor subtypes to establish an official nomenclature framework.
What was found
The abstract reports no numerical findings or quantitative effect sizes. It details the qualitative classification, bodily distribution, physiological functions, and therapeutic utility of the 14 5-HT receptor subtypes.
Why it matters
It provides the authoritative IUPHAR reference framework for serotonin receptor taxonomy and pharmacology, guiding drug discovery and target validation.
Limits
As a narrative review, it contains no new empirical human data, meta-analytic pooling, or quantitative outcome measures. Specific search methods and study selection criteria are not described in the abstract.