Interdependency of Core Temperature and Glabrous Skin Blood Flow in Human Thermoregulation Function: A Pilot Study.
Level 4 - case-series / case-control
Small physiological pilot study and mathematical model fitting without a control group.
PubMed 36305625 · doi:10.1115/1.4056110
What was done
Six human subjects completed two transient environmental thermal stress protocols (12 experimental datasets total) to evaluate the interdependent control of core temperature and glabrous skin blood flow (GSBF) through arteriovenous anastomoses. Researchers developed a coupled nonlinear feedback control system model incorporating core temperature, nonglabrous skin temperature, selective thermal stimulation, and rate-of-change projection terms. The model was tuned to each individual dataset using a nonlinear least-squares curve-fitting algorithm.
What was found
The abstract reports no numerical values, effect sizes, or quantitative goodness-of-fit metrics (such as R² or root-mean-square error). It notes that fitting unique model coefficients to each of the 12 datasets yielded strong agreement between modeled and experimental trajectories.
Why it matters
This framework characterizes how convective blood flow through glabrous skin interacts dynamically with core temperature, offering a mathematical control algorithm for human thermoregulation modeling.
Limits
The sample size is very small (n = 6), and the abstract does not report participant demographics such as age or sex. The model required individualized parameter tuning for each dataset rather than demonstrating generalizability or predictive power on an independent validation cohort. No quantitative error metrics or physiological baseline numbers are provided in the abstract.
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- supports The palms of the hands are thermoregulators for the human body.