Electrolyte Imbalance and Neurologic Injury.
Level 5 - mechanism / opinion, no new human data
Narrative review without systematic methodology or new empirical human data
PubMed 36790006 · doi:10.2174/1871527322666230215144649
What was done
This focused narrative review examined literature on the reciprocal relationship between major electrolyte disturbances (sodium, potassium, calcium, and magnesium) and acute neurologic injuries, specifically traumatic brain injury, status epilepticus, and acute ischemic stroke. It evaluated pathophysiology, clinical manifestations, iatrogenic causes, and therapeutic correction strategies.
What was found
The abstract reports no numerical data, effect sizes, or study counts. It qualitatively reports that acute neural insults disrupt homeostatic parameters through inflammatory cascades, leading to prolonged dysnatremias, dyskalemias, dyscalcemias, and dysmagnesemias that exacerbate morbidity and mortality. It emphasizes the necessity of early recognition and identifies challenges in tailoring replacement protocols to specific injury types.
Why it matters
Electrolyte derangements frequently compound acute brain damage, underlining the importance of developing injury-tailored correction guidelines in neurocritical care rather than relying on uniform replacement strategies.
Limits
As a narrative review, the paper provides no systematic search strategy, quality appraisal of included studies, sample sizes, or quantitative meta-analysis. No primary human data or statistical estimates of treatment outcomes are reported in the abstract.
Cited by
- supports Electrolytes such as sodium, magnesium, and potassium are vital for the normal functioning of all cells, especially neurons.