The Key Role of Mitochondrial Function in Health and Disease.
Level 5 - mechanism / opinion, no new human data
Narrative review without systematic literature search or empirical pooling
PubMed 37107158 · doi:10.3390/antiox12040782
What was done
This is a narrative review synthesizing literature on the role of mitochondrial bioenergetics, mitochondrial DNA mutations, aging, and physical inactivity in the pathogenesis of chronic non-communicable diseases such as type 2 diabetes, cardiovascular disease, cancer, and Alzheimer's disease. It discusses evolutionary context and the role of exercise prescription in metabolic rehabilitation.
What was found
The abstract presents a theoretical synthesis and conceptual discussion; it reports no quantitative data, effect sizes, statistical comparisons, or study counts.
Why it matters
It highlights physical inactivity as a direct contributor to mitochondrial impairment and argues for structured, individualized exercise prescriptions to prevent and manage chronic metabolic diseases.
Limits
As an unsystematic narrative review, it contains no original empirical data, quantitative synthesis, or pre-specified methodology. The abstract provides no specific population parameters or measured outcomes.
Cited by
- partial Mitochondrial dysfunction is the common root cause of major chronic diseases including cancer, type 2 diabetes, depression, and Alzheimer's disease.