Interactions between mitochondrial dysfunction and other hallmarks of aging: Paving a path toward interventions that promote healthy old age.
Level 5 - mechanism / opinion, no new human data
Narrative review synthesizing mechanistic concepts without systematic methodology or original human data.
PubMed 37497653 · doi:10.1111/acel.13942
What was done
This is a narrative review synthesizing conceptual models and literature regarding the crosstalk between different hallmarks of aging, centering specifically on the role and interactions of mitochondrial dysfunction across systems and tissues over time.
What was found
The abstract provides no empirical numbers or quantitative findings. It presents conceptual perspectives emphasizing that aging phenotypes likely result from concurrent, multi-hallmark molecular perturbations rather than isolated pathways, with mitochondrial dysfunction serving as a primary node of hallmark interconnectedness.
Why it matters
Understanding bidirectional cause-and-effect relationships and spatial-temporal dynamics between mitochondrial dysfunction and other aging hallmarks is essential for identifying targets for multi-modal longevity interventions.
Limits
The paper is a conceptual narrative review and provides no new empirical data, quantitative synthesis, or systematic search methodology. Clinical applicability and translational potential remain unquantified.
Cited by
- context Mitochondrial dysfunction is the common root cause of major chronic diseases including cancer, type 2 diabetes, depression, and Alzheimer's disease.