Effect of various photobiomodulation regimens on breast cancer-related lymphedema: A systematic review and meta-analysis.
Level 1 - systematic review of randomized trials
Systematic review and meta-analysis of clinical studies
PubMed 38129368 · doi:10.1007/s10103-023-03959-z
What was done
Authors searched four online databases (Embase, Ovid Medline, Cochrane, and Cinahl) to evaluate the effect of low-level laser therapy (LLLT/photobiomodulation) on breast cancer-related lymphedema (BCRL). Studies comparing LLLT with non-LLLT controls were reviewed by two authors and analyzed based on treatment area, treatment regimen, and total treatment sessions.
What was found
The abstract reported no exact numerical effect sizes, confidence intervals, or p-values. Axillary treatment yielded significantly better post-treatment quality of life; protocols delivering 1.5-2 J/cm² three times per week achieved significantly greater swelling reduction immediately post-treatment and at 1-3 months follow-up; and protocols with more than 15 sessions showed significantly better outcomes for swelling reduction and grip strength.
Why it matters
This meta-analysis delineates specific photobiomodulation parameters (axillary focus, 3 sessions/week at 1.5-2 J/cm², >15 total sessions) that may optimize clinical outcomes for breast cancer-related lymphedema.
Limits
The abstract does not disclose the number of included studies, total participant sample size, or exact quantitative effect sizes. Follow-up was short (1-3 months), and findings require confirmation in larger, long-term trials.