Broadening dementia risk models: building on the 2024 Lancet Commission report for a more inclusive global framework.
Level 5 - mechanism / opinion, no new human data
Conceptual modeling framework and narrative review based on secondary data
PubMed 41004922 · doi:10.1016/j.ebiom.2025.105950
What was done
The authors applied a multidimensional framework incorporating gender equity considerations, poverty, wealth shocks, income inequality, and HIV infection rates to expand upon the 14 modifiable dementia risk factors published in the 2024 Lancet Commission report.
What was found
The 2024 Lancet Commission report accounted for approximately 45% of global dementia cases across 14 factors, with 57% of those factors being more prevalent in men. Incorporating four additional factors—poverty, wealth shocks, income inequality, and HIV—is estimated to increase the proportion of potentially preventable dementia cases to approximately 65%. Under this expanded model, approximately 56% of modifiable risks disproportionately impact women.
Why it matters
Expanding dementia prevention frameworks to include socioeconomic factors and HIV improves risk modeling for underrepresented populations and better aligns global risk distributions with the higher prevalence of dementia in women.
Limits
The abstract describes a conceptual model and framework rather than an empirical trial or prospective cohort study; specific underlying dataset sample sizes, effect sizes, statistical methodologies, and confidence intervals are not reported in the abstract.