Targeting neuroplasticity in old brain: restoring synapse with cognitive strategies.
Level 5 - mechanism / opinion, no new human data
Narrative review without systematic review methodology or original empirical data
PubMed 41741808 · doi:10.1007/s10522-026-10408-1
What was done
Narrative review summarizing mechanisms of neuroplasticity (including synaptic plasticity, adult neurogenesis, and functional reorganization) underlying cognitive aging, and discussing intervention approaches such as cognitive training, physical exercise, and pharmacotherapies.
What was found
The abstract reports no numerical findings or quantitative effect sizes. It notes that synaptic plasticity and functional reorganization help preserve cognitive function, while adult human neurogenesis remains controversial and limited compared to rodent models. It also notes that oxidative stress, neuroinflammation, and hormonal shifts worsen neuroplastic decline.
Why it matters
Provides a broad theoretical overview of how targeted lifestyle and pharmacological strategies might modulate neuroplasticity mechanisms to address age-related cognitive decline.
Limits
As a narrative review, it presents no original empirical data, sample size, or systematic synthesis methodology. Specific clinical outcomes, effect magnitudes, and personalized intervention protocols are not quantified in the abstract.
Cited by
- supports Neuroplasticity exists throughout the human lifespan.
- supports Neuroplasticity continues throughout the entire human lifespan.