Christof Koch
Christof Koch is a neuroscientist who serves as an investigator at the Allen Institute for Brain Science and the chief scientist at the Tiny Blue Dot Foundation. His research focuses on the neural mechanisms of consciousness, including testing integrated information theory, global neuronal workspace theory, and covert consciousness. Additionally, his published work examines visual sensory processing, cortical circuit architecture, and neurotechnology integrating electrophysiology and optogenetics.
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Publications
- Consciousness and Controlled Donation After Circulatory Determination of Death.
- Protocol for testing global neuronal workspace and integrated information theories of consciousness in non-human primates and mice.
- Neuropixels Opto: combining high-resolution electrophysiology and optogenetics.
- Pupil-DLC: An open-source deep learning pipeline for scalable, marker-less tracking of pupil dynamics across conscious and unconscious states.
- Map of spiking activity underlying change detection in the mouse visual system.
- Hierarchical substrates of prediction in visual cortical spiking.
- Deciphering neuronal variability across states reveals dynamic sensory encoding.
- Neuropixels Opto: Combining high-resolution electrophysiology and optogenetics.
- An ethical framework to assess covert consciousness.
- Consciousness or pseudo-consciousness? A clash of two paradigms.
- Integrating multimodal data to understand cortical circuit architecture and function.
- Thalamic feedback shapes brain responses evoked by cortical stimulation in mice and humans.
- Adversarial testing of global neuronal workspace and integrated information theories of consciousness.
- The void and the brain.
- Covert consciousness: what's in a name?
- Ultra-high-density Neuropixels probes improve detection and identification in neuronal recordings.
- Evidence from spatial transcriptomics for the mosaic hypothesis and pure cell types in the cortex.
- Map of spiking activity underlying change detection in the mouse visual system.
- Consciousness: Moving forward by going backward.
- Predicting neural responses to intra- and extra-cranial electric brain stimulation by means of the reciprocity theorem.
- Cell class-specific electric field entrainment of neural activity.
- Ultra-high density electrodes improve detection, yield, and cell type identification in neuronal recordings.
- Backward masking in mice requires visual cortex.
- Thalamic feedback shapes brain responses evoked by cortical stimulation in mice and humans.
- Behavioral strategy shapes activation of the Vip-Sst disinhibitory circuit in visual cortex.
- Christof Koch.
- Transition to chaos separates learning regimes and relates to measure of consciousness in recurrent neural networks.
- Cell-class-specific electric field entrainment of neural activity.
- Testing the Conjecture That Quantum Processes Create Conscious Experience.
- Cell-class-specific electric field entrainment of neural activity.
- Author Correction: BigNeuron: a resource to benchmark and predict performance of algorithms for automated tracing of neurons in light microscopy datasets.
- Brain organoids, consciousness, ethics and moral status.
- Influence of claustrum on cortex varies by area, layer, and cell type.
- Simulations of cortical networks using spatially extended conductance-based neuronal models.
- An adversarial collaboration protocol for testing contrasting predictions of global neuronal workspace and integrated information theory.
- Regional and cell-type-specific afferent and efferent projections of the mouse claustrum.
- A survey of neurophysiological differentiation across mouse visual brain areas and timescales.
- Measuring Consciousness in the Intensive Care Unit.
- BigNeuron: a resource to benchmark and predict performance of algorithms for automated tracing of neurons in light microscopy datasets.
- Do not go gently into that good night: The dying brain and its paradoxically heightened electrical activity.
- Cortico-thalamo-cortical interactions modulate electrically evoked EEG responses in mice.
- Sharing neurophysiology data from the Allen Brain Observatory.
- Uncovering circuit mechanisms of current sinks and sources with biophysical simulations of primary visual cortex.
- Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex.
- Author Correction: Human neocortical expansion involves glutamatergic neuron diversification.
- Measuring Stimulus-Evoked Neurophysiological Differentiation in Distinct Populations of Neurons in Mouse Visual Cortex.
- Multi-regional module-based signal transmission in mouse visual cortex.
- Local connectivity and synaptic dynamics in mouse and human neocortex.
- Author Correction: Comparative cellular analysis of motor cortex in human, marmoset and mouse.
- IIT, half masked and half disfigured.
- Single-neuron models linking electrophysiology, morphology, and transcriptomics across cortical cell types.
- Next-generation brain observatories.
- Single-neuron models linking electrophysiology, morphology, and transcriptomics across cortical cell types.
- Multi-modal characterization and simulation of human epileptic circuitry.
- Computational Models of Interoception and Body Regulation.
- Survey of spiking in the mouse visual system reveals functional hierarchy.
- Relationship between simultaneously recorded spiking activity and fluorescence signal in GCaMP6 transgenic mice.
- Making the hard problem of consciousness easier.
- Perceptual awareness negativity: a physiological correlate of sensory consciousness.
- Reconciling functional differences in populations of neurons recorded with two-photon imaging and electrophysiology.
- Single-cell and single-nucleus RNA-seq uncovers shared and distinct axes of variation in dorsal LGN neurons in mice, non-human primates, and humans.
- Adaptation supports short-term memory in a visual change detection task.
- Signature morpho-electric, transcriptomic, and dendritic properties of human layer 5 neocortical pyramidal neurons.
- Comparative cellular analysis of motor cortex in human, marmoset and mouse.
- Human neocortical expansion involves glutamatergic neuron diversification.
- Morphological diversity of single neurons in molecularly defined cell types.
- Removing independent noise in systems neuroscience data using DeepInterpolation.
- The Brain Electric.
- A large-scale standardized physiological survey reveals functional organization of the mouse visual cortex.
- Transcriptomic evidence that von Economo neurons are regionally specialized extratelencephalic-projecting excitatory neurons.
- Systematic Integration of Structural and Functional Data into Multi-scale Models of Mouse Primary Visual Cortex.
- The Allen Mouse Brain Common Coordinate Framework: A 3D Reference Atlas.
- Distinct Transcriptomic Cell Types and Neural Circuits of the Subiculum and Prosubiculum along the Dorsal-Ventral Axis.
- Hot or not.
- Brain Bridging.
- Integrated Morphoelectric and Transcriptomic Classification of Cortical GABAergic Cells.
- Brain Modeling ToolKit: An open source software suite for multiscale modeling of brain circuits.
- Tales of the Dying Brain.
- High-density extracellular probes reveal dendritic backpropagation and facilitate neuron classification.
- Classification of electrophysiological and morphological neuron types in the mouse visual cortex.
- Conserved cell types with divergent features in human versus mouse cortex.
- Neural precursors of decisions that matter-an ERP study of deliberate and arbitrary choice.
- Hierarchical organization of cortical and thalamic connectivity.
- Is Death Reversible?
- Proust among the Machines.
- Conscious machines: Defining questions.
- Challenges and opportunities for large-scale electrophysiology with Neuropixels probes.
- Systematic generation of biophysically detailed models for diverse cortical neuron types.
- Generalized leaky integrate-and-fire models classify multiple neuron types.
- Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method.
- The ethics of experimenting with human brain tissue.
- What Is Consciousness?
- Human single neuron activity precedes emergence of conscious perception.
- A robust ex vivo experimental platform for molecular-genetic dissection of adult human neocortical cell types and circuits.
- What Is Consciousness?
- BioNet: A Python interface to NEURON for modeling large-scale networks.
- Sparse recurrent excitatory connectivity in the microcircuit of the adult mouse and human cortex.
- Shared and distinct transcriptomic cell types across neocortical areas.
- h-Channels Contribute to Divergent Intrinsic Membrane Properties of Supragranular Pyramidal Neurons in Human versus Mouse Cerebral Cortex.
- Visual physiology of the layer 4 cortical circuit in silico.
- Paul G. Allen (1953-2018).
- Comprehensive cellular-resolution atlas of the adult human brain.
- Spatial Organization of Chromatic Pathways in the Mouse Dorsal Lateral Geniculate Nucleus.
- Scene-selective coding by single neurons in the human parahippocampal cortex.
- From Maxwell's equations to the theory of current-source density analysis.
- Persistent Single-Neuron Activity during Working Memory in the Human Medial Temporal Lobe.
- A Computational Analysis of the Function of Three Inhibitory Cell Types in Contextual Visual Processing.
- A robot for high yield electrophysiology and morphology of single neurons in vivo.
- Are the Neural Correlates of Consciousness in the Front or in the Back of the Cerebral Cortex? Clinical and Neuroimaging Evidence.
- Fully integrated silicon probes for high-density recording of neural activity.
- How to Make a Consciousness Meter.
- Are we underestimating the richness of visual experience?
- Effects of Chronic Sleep Restriction during Early Adolescence on the Adult Pattern of Connectivity of Mouse Secondary Motor Cortex.
- Inferring cortical function in the mouse visual system through large-scale systems neuroscience.
- Comprehensive cellular-resolution atlas of the adult human brain.
- Posterior and anterior cortex - where is the difference that makes the difference?
- 25th Annual Computational Neuroscience Meeting: CNS-2016.
- Worldwide initiatives to advance brain research.
- The Computational Properties of a Simplified Cortical Column Model.
- Big Science, Team Science, and Open Science for Neuroscience.