Dominic D'Agostino
Dominic D'Agostino is a researcher focusing on metabolism, nutritional therapies, and exercise physiology. His published research investigates the physiological, metabolic, and cognitive effects of ketogenic diets, carbohydrate ingestion, and exogenous ketone supplementation. He has also studied metabolic interventions in disease models, including epilepsy, glioblastoma, and the application of hyperbaric oxygen therapy.
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Publications
- Carbohydrate Ingestion on Exercise Metabolism and Physical Performance.
- Disparate Hepatic Mitochondrial and Inflammatory Effects of Ketone Supplements.
- The Effects of 31-Day Exogenous Ketone Consumption on Running Performance, Cognitive Function, Metabolism, Body Composition, Hemodynamics, and Mood in Recreational Runners: A Randomized-Control Trial.
- Carbohydrate ingestion eliminates hypoglycemia and improves endurance exercise performance in triathletes adapted to very low- and high-carbohydrate isocaloric diets.
- Editorial: Review of hyperbaric therapy & hyperbaric oxygen therapy in the treatment of neurological disorders according to dose of pressure and hyperoxia.
- Olfaction-based learned preference assessment without the use of motivational fear or motivational weight loss.
- Exogenous Ketone Supplementation Enhances the Anti-Epileptic Effect of Levetiracetam in Wistar Albino Glaxo/Rijswijk Rats.
- From glucose to histone modification: sex-specific metabolic responses to ketogenic therapy in VM/Dk mice.
- Substrate Oxidation Does Not Influence Middle Distance Running Performance: A Randomized Controlled Crossover Trial.
- Divergent Hepatic Outcomes of Chronic Ketone Supplementation: Ketone Salts Preserve Liver Health While Ketone Esters and Precursors Drive Inflammation and Steatosis.
- A Ketone Monoester with Carbohydrate Improves Cognitive Measures Postexercise, but Not Performance in Trained Females.
- Ketone ester supplementation of Atkins-type diet prolongs survival in an orthotopic xenograft model of glioblastoma.
- Exogenous Ketone Supplement Administration Abrogated Isoflurane-Anesthesia-Induced Increase in Blood Glucose Level in Female WAG/Rij Rats.
- The Metabolic and Endocrine Effects of a 12-Week Allulose-Rich Diet.
- International society of sports nutrition position stand: ketogenic diets.
- Putative Role of Adenosine A1 Receptors in Exogenous Ketone Supplements-Evoked Anti-Epileptic Effect.
- Neuroregeneration Improved by Sodium-D,L-Beta-Hydroxybutyrate in Primary Neuronal Cultures.
- Oral Administration of a Novel, Synthetic Ketogenic Compound Elevates Blood β-Hydroxybutyrate Levels in Mice in Both Fasted and Fed Conditions.
- Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma.
- Ketone supplementation abolished isoflurane anesthesia-induced elevation in blood glucose level and increased recovery time from anesthesia in Wistar Albino Glaxo Rijswijk rats.
- Low and high carbohydrate isocaloric diets on performance, fat oxidation, glucose and cardiometabolic health in middle age males.
- Metabolic and ruck performance effects of a novel, light-weight, energy-dense ketogenic bar.
- A Glutamate Scavenging Protocol Combined with Deanna Protocol in SOD1-G93A Mouse Model of ALS.
- Metabolic management of microenvironment acidity in glioblastoma.
- Elevated LDL-cholesterol levels among lean mass hyper-responders on low-carbohydrate ketogenic diets deserve urgent clinical attention and further research.
- Enhancement of Ketone Supplements-Evoked Effect on Absence Epileptic Activity by Co-Administration of Uridine in Wistar Albino Glaxo Rijswijk Rats.
- Exogenous ketone salts inhibit superoxide production in the rat caudal solitary complex during exposure to normobaric and hyperbaric hyperoxia.
- Systematic Review - Neuroprotection of ketosis in acute injury of the mammalian central nervous system: A meta-analysis.
- Exogenous ketone ester delays CNS oxygen toxicity without impairing cognitive and motor performance in male Sprague-Dawley rats.
- Case Report: Ketogenic Diet Is Associated With Improvements in Chronic Obstructive Pulmonary Disease.
- Adenosine Receptors Modulate the Exogenous Ketogenic Supplement-Evoked Alleviating Effect on Lipopolysaccharide-Generated Increase in Absence Epileptic Activity in WAG/Rij Rats.
- Ketone Bodies Impact on Hypoxic CO 2 Retention Protocol During Exercise.
- Ketone Supplementation: Meeting the Needs of the Brain in an Energy Crisis.
- Effects of Ketogenic Dieting on Body Composition, Strength, Power, and Hormonal Profiles in Resistance Training Men.
- Evaluation of the safety and tolerability of a nutritional Formulation in patients with ANgelman Syndrome (FANS): study protocol for a randomized controlled trial.
- Inhibition of adenosine A1 receptors abolished the nutritional ketosis-evoked delay in the onset of isoflurane-induced anesthesia in Wistar Albino Glaxo Rijswijk rats.
- Ketone Bodies Attenuate Wasting in Models of Atrophy.
- Effects of an Exogenous Ketone Supplement on Five-Kilometer Running Performance.
- Metabolic switching is impaired by aging and facilitated by ketosis independent of glycogen.
- Exogenous Dietary Ketone Ester Decreases Body Weight and Adiposity in Mice Housed at Thermoneutrality.
- Exogenous Ketone Supplements Improved Motor Performance in Preclinical Rodent Models.
- Dose response of a novel exogenous ketone supplement on physiological, perceptual and performance parameters.
- Age- and Sex-Dependent Modulation of Exogenous Ketone Supplement-Evoked Effects on Blood Glucose and Ketone Body Levels in Wistar Albino Glaxo Rijswijk Rats.
- Human Adaptations to Multiday Saturation on NASA NEEMO.
- Genetic variants for personalised management of very low carbohydrate ketogenic diets.
- Targeting the Warburg effect for cancer treatment: Ketogenic diets for management of glioma.
- Delaying latency to hyperbaric oxygen-induced CNS oxygen toxicity seizures by combinations of exogenous ketone supplements.
- Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements.
- Anticatabolic Effects of Ketone Bodies in Skeletal Muscle.
- Exogenous Ketone Supplementation Decreased the Lipopolysaccharide-Induced Increase in Absence Epileptic Activity in Wistar Albino Glaxo Rijswijk Rats.
- Potential Protective Mechanisms of Ketone Bodies in Migraine Prevention.
- Concentration-Dependent Effects of a Dietary Ketone Ester on Components of Energy Balance in Mice.
- Therapeutic Potential of Exogenous Ketone Supplement Induced Ketosis in the Treatment of Psychiatric Disorders: Review of Current Literature.
- Exogenous Ketones Lower Blood Glucose Level in Rested and Exercised Rodent Models.
- Ketone Administration for Seizure Disorders: History and Rationale for Ketone Esters and Metabolic Alternatives.
- Anxiolytic Effect of Exogenous Ketone Supplementation Is Abolished by Adenosine A1 Receptor Inhibition in Wistar Albino Glaxo/Rijswijk Rats.
- Commentary: Ketone Diester Ingestion Impairs Time-Trial Performance in Professional Cyclists.
- Nutritional ketosis delays the onset of isoflurane induced anesthesia.
- Comparison of Powerlifting Performance in Trained Men Using Traditional and Flexible Daily Undulating Periodization.
- Corrigendum: Exogenous Ketone Supplements Reduce Anxiety-Related Behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk Rats.
- Press-pulse: a novel therapeutic strategy for the metabolic management of cancer.
- Structural homologies between phenformin, lipitor and gleevec aim the same metabolic oncotarget in leukemia and melanoma.
- Need for new review of article on ketogenic dietary regimes for cancer patients.
- Complex I inhibition augments dichloroacetate cytotoxicity through enhancing oxidative stress in VM-M3 glioblastoma cells.
- Adenosine A1 Receptor Antagonism Abolished the Anti-seizure Effects of Exogenous Ketone Supplementation in Wistar Albino Glaxo Rijswijk Rats.
- The 1-Week and 8-Month Effects of a Ketogenic Diet or Ketone Salt Supplementation on Multi-Organ Markers of Oxidative Stress and Mitochondrial Function in Rats.
- Different calorie restriction treatments have similar anti-seizure efficacy.
- Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle.
- Effects of exogenous ketone supplementation on blood ketone, glucose, triglyceride, and lipoprotein levels in Sprague-Dawley rats.
- Ketone ester supplementation attenuates seizure activity, and improves behavior and hippocampal synaptic plasticity in an Angelman syndrome mouse model.
- Fueling Performance: Ketones Enter the Mix.
- Exogenous Ketone Supplements Reduce Anxiety-Related Behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk Rats.
- Hyperbaric Environment: Oxygen and Cellular Damage versus Protection.
- Metabolic therapy: a new paradigm for managing malignant brain cancer.
- The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.
- Anticonvulsant properties of an oral ketone ester in a pentylenetetrazole-model of seizure.
- Cancer as a metabolic disease: implications for novel therapeutics.
- Metabolic therapy with Deanna Protocol supplementation delays disease progression and extends survival in amyotrophic lateral sclerosis (ALS) mouse model.
- Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats.
- The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer.
- Ketogenic diet improves motor performance but not cognition in two mouse models of Alzheimer's pathology.
- Ketogenic diet does not affect strength performance in elite artistic gymnasts.
- Effects of hyperbaric gases on membrane nanostructure and function in neurons.
- Heme oxygenase is necessary for the excitatory response of cultured neonatal rat rostral ventrolateral medulla neurons to hypoxia.
- Superoxide (*O2- ) production in CA1 neurons of rat hippocampal slices exposed to graded levels of oxygen.