Tony Wyss-Coray
Tony Wyss-Coray is a professor of neurology at the Stanford School of Medicine and the Director of the Phil and Penny Knight Initiative for Brain Resilience. His research focuses on the biology of aging, brain health, and neurodegenerative disorders such as Alzheimer's disease. His published work investigates proteomic profiling across organs, blood- and CSF-based biomarkers of biological aging, and the cellular and immune mechanisms influencing cognitive decline and neurodegeneration.
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Publications
- OMG! A proteomic determinant of neurodegenerative resiliency.
- CSF proteomic profiling with amyloid and tau pathology identifies distinctive sex-specific alteration of multiple proteins involved in Alzheimer's disease.
- Multi-modal choroid plexus pathology in aging and Alzheimer's disease.
- Ageing promotes microglial accumulation of slow-degrading synaptic proteins.
- Past, present and future perspectives on the science of aging.
- In vivo CRISPR screening identifies SAGA complex members as key regulators of hematopoiesis.
- Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition.
- APOE-stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease.
- MiRNAs shape mouse age-independent tissue adaptation to spaceflight via ECM and developmental pathways.
- Accelerated multi-organ proteomic aging is detectable decades before dementia onset.
- Cellular Aging Signatures in the Plasma Proteome Record Human Health and Disease.
- Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish.
- Simultaneous spatial transcriptomics and morphology profiling as tools to explore how microglia change with age.
- Obesity supersizes macrophage and neutrophil activation after stroke while lipid droplets play a protective role.
- Blood-brain barrier dysfunction predicts cognitive trajectory after ischemic stroke.
- PLCG2 signaling and genetic resilience in Alzheimer's disease.
- Large-scale CSF and plasma proteomics reveal immune, synaptic, and extracellular matrix disruptions across neurodegenerative diseases.
- Mucin-binding protein shuttles enable delivery of brain-targeted therapeutics.
- Toward actionable interventions in human aging (12th ARDD meeting, 2025).
- Plasma proteomic signatures of preclinical Alzheimer's disease in clinically unimpaired older adults.
- Replacement-Based Ageing Interventions for Systemic Rejuvenation: Shaping Longevity Science and Clinical Directions.
- Low overlap of plasma and CSF protein quantitative trait loci affects protein discovery for neurological disease.
- Plasma proteomics of APOE genotype: age-specific analyses in UK population-based cohorts.
- Effects of α-synuclein pathology on synaptic dysfunction and clinical outcomes in normal aging.
- Plasma proteomics link menopause timing to brain aging and dementia risk.
- Engulfment by brain macrophages in a short-lived vertebrate.
- Cross-species transcriptomic integration reveals a MIRO1-mediated macrophage-T cell axis in glioma.
- Plasma proteomics link menopause timing to brain aging and dementia risk.
- Plasma proteomics reveals divergent sex-specific senescence and bone biology signatures across neurodegenerative diseases.
- Plasma proteomic signatures of cellular aging predict human disease.
- Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition.
- Biological aging clocks in health and disease.
- Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease.
- Plasma Aβ 42 /Aβ 40 is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum.
- Recommendations for implementing the Hevolution Alliance for Aging Biomarkers initiative.
- Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish.
- A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegeneration.
- Glycocalyx dysregulation impairs blood-brain barrier in ageing and disease.
- A high-throughput assay platform to discover small molecule activators of the phospholipase PLC-γ2 to treat Alzheimer's disease.
- Proteomic organ-specific ageing signatures and 20-year risk of age-related diseases: the Whitehall II observational cohort study.
- Color-neutral and reversible tissue transparency enables longitudinal deep-tissue imaging in live mice.
- Social disadvantage accelerates aging.
- Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures across the Alzheimer disease continuum.
- Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease.
- A spatio-temporal brain miRNA expression atlas identifies sex-independent age-related microglial driven miR-155-5p increase.
- A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease.
- Invigorating discovery and clinical translation of aging biomarkers.
- Large-scale Plasma Proteomic Profiling Unveils Novel Diagnostic Biomarkers and Pathways for Alzheimer's Disease.
- Translating the Post-Mortem Brain Multi-Omics Molecular Taxonomy of Alzheimer's Dementia to Living Humans.
- Parkinson's disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction.
- A spatio-temporal brain miRNA expression atlas identifies sex-independent age-related microglial driven miR-155-5p increase.
- Large-scale plasma proteomic profiling unveils diagnostic biomarkers and pathways for Alzheimer's disease.
- In vivo CRISPR screening identifies SAGA complex members as key regulators of hematopoiesis.
- Synaptic proteins that aggregate and degrade slower with aging accumulate in microglia.
- Cell-surface proteomic profiling identifies CD72 as a regulator of microglial tiling.
- Plasma proteomics links brain and immune system aging with healthspan and longevity.
- The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging.
- Disruption of the cerebrospinal fluid-plasma protein balance in cognitive impairment and aging.
- Protein-based Diagnosis and Analysis of Co-pathologies Across Neurodegenerative Diseases: Large-Scale AI-Boosted CSF and Plasma Classification.
- Gpr37 modulates the severity of inflammation-induced GI dysmotility by regulating enteric reactive gliosis.
- Protein-based Diagnosis and Analysis of Co-pathologies Across Neurodegenerative Diseases: Large-Scale AI-Boosted CSF and Plasma Classification.
- Luminal Cerebrovascular Proteomics.
- Defined human tri-lineage brain microtissues.
- Color-neutral and reversible tissue transparency enables longitudinal deep-tissue imaging in live mice.
- Characterizing Post-Mortem Brain Molecular Taxonomy of Cognitive Resilience and Translating it to Living Humans.
- Angiopoietin signalling is a central axis of amyloid-driven vascular dysfunction in Alzheimer's disease.
- Isolation and Imaging of Microvessels From Brain Tissue.
- Eight decades of follow-up link life course exposures to proteomic organ ageing and longevity.
- Age-related microbiome metabolites alter RNA splicing and chromatin accessibility in the brain.
- Core Activation Program and Selective Regional Responsiveness of Microglia in Aging and Parabiosis.
- Plasma proteomic signatures of preclinical Alzheimer's disease biomarkers and memory in clinically unimpaired older adults.
- Long-read genome sequencing and multi-omics in aging and neurodegeneration.
- Cross-Species Transcriptomic Integration Reveals a Conserved, MIRO1-Mediated Macrophage-to-T Cell Signaling Axis Driving Immunosuppression in Glioma.
- Spatial and single-cell transcriptomics reveal the reorganization of cerebellar microglia with aging.
- Autonomous AI Agents Discover Aging Interventions from Millions of Molecular Profiles.
- Characterizing expression changes in noncoding RNAs during aging and heterochronic parabiosis across mouse tissues.
- ZEBRA: a hierarchically integrated gene expression atlas of the murine and human brain at single-cell resolution.
- Post-translational modifications linked to preclinical Alzheimer's disease-related pathological and cognitive changes.
- Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer's disease.
- Systematic proteomics in Autosomal dominant Alzheimer's disease reveals decades-early changes of CSF proteins in neuronal death, and immune pathways.
- Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures for asymptomatic and symptomatic Alzheimer's disease.
- Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson's disease.
- APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia.
- SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination.
- Myeloid cell replacement is neuroprotective in chronic experimental autoimmune encephalomyelitis.
- CSF proteomic profiling with amyloid/tau positivity identifies distinctive sex-different alteration of multiple proteins involved in Alzheimer's disease.
- Gpr37 modulates the severity of inflammation-induced GI dysmotility by regulating enteric reactive gliosis.
- A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer's mouse model.
- Human tNeurons reveal aging-linked proteostasis deficits driving Alzheimer's phenotypes.
- Plasma proteomics in the UK Biobank reveals youthful brains and immune systems promote healthspan and longevity.
- Plasma and CSF biomarkers of aging and cognitive decline in Caribbean vervets.
- CSF proteomics identifies early changes in autosomal dominant Alzheimer's disease.
- Parkinson's disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction.
- Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity.
- Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicates causal proteins for Alzheimer's disease.
- A 3'UTR Insertion Is a Candidate Causal Variant at the TMEM106B Locus Associated With Increased Risk for FTLD-TDP.
- Author Correction: Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17.
- Sirtuin-2, NAD-Dependent Deacetylase, Is a New Potential Therapeutic Target for HIV-1 Infection and HIV-Related Neurological Dysfunction.
- Activated immune cells drive neurodegeneration in an Alzheimer's model.
- Augmentation of a neuroprotective myeloid state by hematopoietic cell transplantation.
- Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain.
- Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and informs causal proteins for Alzheimer's disease.
- Proteomics of brain, CSF, and plasma identifies molecular signatures for distinguishing sporadic and genetic Alzheimer's disease.
- A 3'UTR Insertion Is a Candidate Causal Variant at the TMEM106B Locus Associated with Increased Risk for FTLD-TDP.
- Ageing-associated small RNA cargo of extracellular vesicles.
- APOE4/4 is linked to damaging lipid droplets in Alzheimer's microglia.
- Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice.
- Atlas of the aging mouse brain reveals white matter as vulnerable foci.
- Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease.
- A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer's mouse model.
- Cholesterol 24-hydroxylase at the choroid plexus contributes to brain immune homeostasis.
- Organ aging signatures in the plasma proteome track health and disease.
- An automated feeding system for the African killifish reveals the impact of diet on lifespan and allows scalable assessment of associative learning.
- Performance of a fully-automated Lumipulse plasma phospho-tau181 assay for Alzheimer's disease.
- GhostKnockoff inference empowers identification of putative causal variants in genome-wide association studies.
- Cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment.
- Limited Proteolysis-Mass Spectrometry Reveals Aging-Associated Changes in Cerebrospinal Fluid Protein Abundances and Structures.
- An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer's disease.
- Publisher Correction: Limited proteolysis-mass spectrometry reveals aging-associated changes in cerebrospinal fluid protein abundances and structures.
- Author Correction: Structural changes in cerebrospinal fluid proteins are associated with brain aging.