Linden · Perception 1999 · interventional case series · n=4

The myth of upright vision. A psychophysical and functional imaging study of adaptation to inverting spectacles.

Cited 87 times in the scientific literature.

Level 4 - case-series / case-control

Small experimental case series with psychophysical testing and fMRI (graded by design analogy)

PubMed 10664787 · doi:10.1068/p2820 · record verified 2026-08-26

What was done

Four subjects wore inverting prisms and mirror spectacles continuously for periods of six to ten days. Researchers assessed visuomotor adaptation, subjective reports of upright vision, perception of shape from shading, and early visual cortex retinotopy using functional magnetic resonance imaging (fMRI).

What was found

The abstract reports no numerical data. Subjects demonstrated rapid adaptation of visuomotor functions without reporting a return of upright vision. Transformed visual image persistence was confirmed via shape-from-shading perception, and fMRI revealed no retinotopic reorganization in early visual cortical areas.

Why it matters

This study provides evidence against historical claims that wearing inverting optics leads to a perceptual reinversion to upright vision, suggesting motor adaptation occurs without early cortical sensory remapping.

Limits

The sample size is extremely small (n = 4), adaptation was limited to 6–10 days, and the abstract reports no quantitative measurements, confidence intervals, or control comparisons.

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