Translational control of viral gene expression in eukaryotes.
Level 5 - mechanism / opinion, no new human data
Narrative review describing molecular mechanisms without systematic search methodology or original human data.
PubMed 10839817 · doi:10.1128/MMBR.64.2.239-280.2000
What was done
This narrative review synthesizes published evidence on the molecular strategies eukaryotic viruses use to hijack host translational machinery, selectively translate viral mRNA, modify host factors, and counter host translational defense mechanisms.
What was found
The abstract reports no numerical findings or statistical data. It qualitatively summarizes that eukaryotic viruses utilize specific viral RNA structural features, recruit and modify host factors, and deploy countermeasures against cellular antiviral translational arrest to ensure preferential viral protein synthesis.
Why it matters
Understanding the molecular mechanisms of viral translational hijacking and host counter-responses illuminates critical steps in viral pathogenesis and identifies potential targets for antiviral intervention.
Limits
As a narrative review, it presents no original experimental data, quantitative effect sizes, or systematic review methodology. The abstract lacks specifics on distinct viral families or comparative host responses.
Cited by
- supports All known viruses rely on the host cell's genetic code and ribosomal translation machinery.