Complete androgen insensitivity syndrome: long-term medical, surgical, and psychosexual outcome.
Level 4 - case-series / case-control
Cross-sectional case series without a control group
PubMed 10946863 · doi:10.1210/jcem.85.8.6742
What was done
Fourteen adult women with documented complete androgen insensitivity syndrome (CAIS) were evaluated via questionnaire and physical examination to assess secondary sexual development, psychosexual status, sexual function, condition knowledge, and satisfaction with prior medical and surgical management.
What was found
Secondary sexual development was judged as satisfactory by both participants and examining physicians. Most participants were satisfied with their psychosexual development and sexual functioning, with noted dissatisfaction linked to sexual abuse in 1 case and marked obesity in 1 case. All 14 women were satisfied with female gender assignment, and none desired gender reassignment. Specific numerical scores and standardized metrics were not reported in the abstract.
Why it matters
Provides descriptive follow-up data on adult psychosexual and surgical outcomes in CAIS, supporting stability of female gender identity and generally favorable long-term satisfaction in this cohort.
Limits
The study is restricted to a very small sample (n = 14), lacks a control or comparison group, relies on subjective survey responses, and the abstract omits quantitative outcome metrics.
Cited by
- supports The vast majority of individuals with complete androgen insensitivity syndrome identify as women and are sexually attracted to men.