Stress-induced hyperglycemia.
Level 5 - mechanism / opinion, no new human data
Narrative review and expert opinion without systematic review methods or primary data
PubMed 11219223 · doi:10.1016/s0749-0704(05)70154-8
What was done
This is a narrative review detailing the mechanisms, clinical consequences, and management strategies for stress-induced hyperglycemia in critically ill hospitalized patients.
What was found
The abstract reports no experimental numbers or effect estimates. It states that stress hyperglycemia results from counterregulatory hormone and cytokine surges frequently compounded by dextrose administration (such as total parenteral nutrition). The authors describe their institutional practice of administering insulin to target plasma glucose concentrations between 150 mg/dL and 200 mg/dL.
Why it matters
The paper outlines early-2000s clinical practice and mechanism-based reasoning in critical care, calling attention to the absence of randomized trial data to guide glycemic targets in hospitalized patients.
Limits
This is a narrative review and institutional practice summary, not an empirical study or systematic review. No original patient data, sample sizes, or quantitative outcome measures are provided.
Cited by
- supports In a stressed or inflammatory environment, serum vitamin D levels decrease while blood glucose levels increase.