Gorzalczany · Journal of ethnopharmacology 2001 · Preclinical comparative experimental study · n=?

Choleretic effect and intestinal propulsion of 'mate' (Ilex paraguariensis) and its substitutes or adulterants.

Cited 91 times in the scientific literature.

Level 5 - mechanism / opinion, no new human data

Preclinical laboratory pharmacology study with no human data

PubMed 11297866 · doi:10.1016/s0378-8741(01)00179-9 · record verified 2026-08-26

What was done

Decoctions of the leaves of Yerba mate (Ilex paraguariensis) and three related species known as substitutes or adulterants (Ilex brevicuspis, Ilex argentina, and Ilex theezans) were tested for their effects on bile flow and intestinal propulsion in an experimental laboratory model.

What was found

The abstract reports no numerical values or statistical metrics. Qualitatively, decoctions of I. paraguariensis and I. brevicuspis stimulated an increase in bile flow, and I. brevicuspis additionally enhanced intestinal propulsion. In contrast, neither I. argentina nor I. theezans exerted any effect on bile flow or intestinal propulsion.

Why it matters

The study provides experimental support for the traditional use of Yerba mate as a choleretic agent and demonstrates that adulteration with other Ilex species could diminish or alter the gastrointestinal properties of commercial mate products.

Limits

The abstract reports no quantitative measurements, effect sizes, sample size, or specific details regarding the experimental protocol or animal model. Findings from preclinical assays cannot be directly extrapolated to human clinical outcomes.

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