Hyde · Nature 2002 · Controlled animal experimental lesion study · n=?

The optic tectum controls visually guided adaptive plasticity in the owl's auditory space map.

Cited 101 times in the scientific literature.

Level 5 - mechanism / opinion, no new human data

Animal basic neuroscience research

PubMed 11780119 · doi:10.1038/415073a · record verified 2026-08-26

What was done

Barn owls were raised wearing optical prism spectacles that horizontally shifted their visual field, paired with a restricted unilateral lesion in the region of the optic tectum encoding frontal space. Researchers assessed subsequent plastic shifts and calibration of the topographic auditory space map within the external nucleus of the inferior colliculus (ICX).

What was found

The unilateral optic tectum lesion abolished prism-induced adaptive adjustments selectively in the frontal auditory space representation on the ipsilesional side, while intact regions of the map continued to recalibrate adaptively. The abstract reports no numerical values or sample counts.

Why it matters

This study shows that the optic tectum acts as an instructive topographic template that directs location-specific plasticity in the auditory space map of the inferior colliculus.

Limits

The study is restricted to barn owls, sample size is omitted from the abstract, and no quantitative metrics or statistical measures are reported. Direct translation to mammalian or human auditory processing remains to be established.

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