Absence of orgasm-induced prolactin secretion in a healthy multi-orgasmic male subject.
Level 4 - case-series / case-control
Case report with small control comparison group
PubMed 11979330 · doi:10.1038/sj.ijir.3900823
What was done
Continuous blood sampling was performed during masturbation-induced orgasm in one healthy multi-orgasmic male subject. His prolactin response across three orgasms was compared with that of nine healthy adult male controls who experienced normal refractory periods.
What was found
The multi-orgasmic case subject demonstrated no prolactin response across three orgasms. Specific numerical values and baseline concentrations were not reported in the abstract.
Why it matters
This study provides mechanistic support for the hypothesis that post-orgasmic prolactin secretion regulates sexual satiation and the male refractory period.
Limits
Findings are limited by the single case subject design (n=1 case, n=9 controls), lack of reported numerical data in the abstract, and absence of measurement of other potential neuroendocrine factors involved in sexual refractory states.
Cited by
- supports Post-orgasm elevation of prolactin in the brain contributes to the male sexual refractory period.