Cancer immunoediting: from immunosurveillance to tumor escape.
Level 5 - mechanism / opinion, no new human data
Narrative review and theoretical framework without primary clinical data
PubMed 12407406 · doi:10.1038/ni1102-991
What was done
The authors reviewed the historical and experimental basis of cancer immunosurveillance to conceptualize the cancer immunoediting framework.
What was found
No numerical data are reported in the abstract. The authors describe cancer immunoediting as a dual-role process responsible for eliminating transformed cells and sculpting tumor immunogenicity to facilitate immune escape in immunocompetent hosts.
Why it matters
This review establishes the foundational immunoediting paradigm that explains both immune-mediated tumor elimination and the selection of immune-evasive cancer phenotypes.
Limits
The abstract provides no primary data, quantitative results, sample size, or clinical population details; it presents a narrative review and theoretical framework.
Cited by
- supports The human immune system actively identifies and eliminates emerging cancer cells on a daily basis.