Grant · Archives of general psychiatry 2004 · cross-sectional survey · n=?

Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions.

Cited 160 times in the scientific literature.

Level 4 - case-series / case-control

Nationally representative cross-sectional survey

PubMed 15289279 · doi:10.1001/archpsyc.61.8.807 · record verified 2026-08-31

What was done

Face-to-face cross-sectional survey of US household and group quarters residents from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). The authors assessed the 12-month prevalence and co-occurrence of DSM-IV alcohol and drug use disorders with independent mood and anxiety disorders (excluding substance-induced disorders and those due to a general medical condition).

What was found

The 12-month prevalence of independent mood disorders was 9.21% (95% CI, 8.78%-9.64%), independent anxiety disorders was 11.08% (95% CI, 10.43%-11.73%), and substance use disorders was 9.35% (95% CI, 8.86%-9.84%). Few individuals with mood or anxiety disorders were classified as having only substance-induced disorders. Positive and statistically significant associations (P < .05) were found between most substance use disorders and independent mood and anxiety disorders.

Why it matters

Shows that co-occurring mood and anxiety disorders in individuals with substance use disorders are overwhelmingly independent rather than substance-induced, arguing against withholding psychiatric treatment in this population.

Limits

The abstract does not state the total sample size or specific odds ratios for individual disorder pairings. The cross-sectional design captures 12-month co-occurrence but cannot determine causal or temporal relationships.

Cited by