Bramble · Nature 2004 · narrative review and comparative evolutionary analysis · n=?

Endurance running and the evolution of Homo.

Cited 1753 times in the scientific literature.

Level 5 - mechanism / opinion, no new human data

Level 5 by design analogy; narrative review and evolutionary theory paper.

PubMed 15549097 · doi:10.1038/nature03052 · record verified 2026-08-30

What was done

The authors reviewed human performance in sustained long-distance running relative to other mammals and synthesized comparative physiological, anatomical, and fossil skeletal evidence related to endurance running capabilities.

What was found

The abstract reports no experimental numbers, sample sizes, or quantitative effect estimates. It reports that humans perform remarkably well at endurance running due to specialized physiological and skeletal adaptations, and that fossil evidence dates the origin of these derived capabilities in the genus Homo to approximately 2 million years ago.

Why it matters

This paper introduced the endurance running hypothesis, arguing that long-distance running capability—rather than just walking—was a major selective force shaping human anatomy.

Limits

The paper is a narrative theoretical review relying on historical and comparative anatomical interpretations rather than experimental trials. The abstract provides no quantitative metrics or sample sizes, and evolutionary selective pressures in deep prehistory cannot be directly observed.

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