The versatile roles of "axon guidance" cues in tissue morphogenesis.
Level 5 - mechanism / opinion, no new human data
Narrative review of basic developmental biology mechanisms without original human data or systematic review methodology
PubMed 15572123 · doi:10.1016/j.devcel.2004.11.002
What was done
This narrative review synthesized findings on the roles of canonical axon guidance cues—Netrins, Slits, Semaphorins, and Ephrins—outside the nervous system, focusing on morphogenesis in lung, mammary, cardiovascular, and kidney tissues.
What was found
The abstract provides no numerical data. It reports that these guidance cues regulate cell-cell and cell-extracellular matrix interactions during organogenesis, as well as the transcription and translation of key morphogenetic genes.
Why it matters
The paper frames axon guidance proteins as general morphogenetic regulators across multiple organ systems rather than neural-specific cues.
Limits
No quantitative findings or literature search methodology are reported in the abstract. The findings are mechanistic developmental biology concepts rather than clinical or human trial data.
Cited by
- supports Netrin and ephrin act as chemoattractants and guidance cues during nervous system wiring.