Proksch · International journal of dermatology 2005 · Controlled intra-individual (split-body) trial · n=?

Bathing in a magnesium-rich Dead Sea salt solution improves skin barrier function, enhances skin hydration, and reduces inflammation in atopic dry skin.

Cited 166 times in the scientific literature.

Level 3 - non-randomized controlled study

Controlled intra-individual trial; randomization is not explicitly stated in the abstract.

PubMed 15689218 · doi:10.1111/j.1365-4632.2005.02079.x · record verified 2026-08-31

What was done

Volunteers with atopic dry skin submerged one forearm for 15 minutes in a 5% magnesium-rich Dead Sea salt solution while the contralateral forearm was submerged in tap water as a control. Transepidermal water loss (TEWL), skin hydration, skin roughness, and skin redness were evaluated at baseline and weekly across a 6-week period.

What was found

The abstract reports no numerical values, confidence intervals, or exact p-values. It states that Dead Sea salt solution immersion significantly improved skin barrier function relative to tap water in a subgroup with elevated baseline TEWL. Skin hydration was enhanced in all treated forearms, and both skin roughness and redness were significantly reduced after salt solution bathing.

Why it matters

These findings suggest that magnesium-rich mineral baths may serve as an effective adjuvant therapy to restore barrier function, increase hydration, and reduce inflammation in atopic dry skin.

Limits

The abstract omits the sample size (n), exact numerical outcomes, variance, and p-values. It does not state whether forearm allocation was randomized or whether outcome assessment was blinded.

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