The genetics of addictions: uncovering the genes.
Level 5 - mechanism / opinion, no new human data
Narrative review without systematic search or primary data synthesis
PubMed 15995696 · doi:10.1038/nrg1635
What was done
Narrative review outlining the genetic basis of addictions, gene-environment interactions, shared neurobiological pathways across psychiatric disorders, and substance-specific versus shared genetic vulnerabilities.
What was found
The abstract provides conceptual synthesis without reporting numerical data, sample sizes, or statistical estimates.
Why it matters
It frames addiction as a heritable psychiatric disorder shaped by distinct substance-specific mechanisms alongside broad neurobiological vulnerability pathways.
Limits
Narrative review design with no empirical data, sample size, or systematic review methodology reported in the abstract.
Cited by
- supports The shared genetic heritability across most addictive substances is estimated to be approximately 0.3 to 0.5.