Fisher · The Journal of comparative neurology 2005 · cross-sectional fMRI study and narrative review · n=17

Romantic love: an fMRI study of a neural mechanism for mate choice.

Cited 397 times in the scientific literature.

Level 4 - case-series / case-control

Small cross-sectional neuroimaging study (n=17) and narrative review.

PubMed 16255001 · doi:10.1002/cne.20772 · record verified 2026-08-26

What was done

Functional magnetic resonance imaging (fMRI) was conducted on 17 individuals reporting intense romantic love to measure brain activation when viewing their beloved, interpreted alongside a comparative evolutionary review of mammalian mate choice and reward circuitry.

What was found

Activation specific to the beloved was localized to the right ventral tegmental area and the right caudate nucleus, dopamine-rich regions involved in reward and motivation. The abstract provides no quantitative activation values, effect sizes, or statistical significance metrics.

Why it matters

The study frames romantic love as a specialized, dopamine-mediated motivational system designed for mate selection rather than simply an emotional state.

Limits

The sample size is very small (n = 17). The abstract provides no quantitative data, control conditions, or demographic details, and fMRI correlation cannot establish whether dopaminergic activation causes romantic attachment.

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