Aphrodisiac potentials of the aqueous extract of Fadogia agrestis (Schweinf. Ex Hiern) stem in male albino rats.
Level 5 - mechanism / opinion, no new human data
Animal study measuring behavioral and hormonal parameters without human subjects
PubMed 16281088 · doi:10.1111/j.1745-7262.2005.00052.x
What was done
Phytochemical screening was performed on an aqueous stem extract of Fadogia agrestis. Male albino rats were orally dosed with 18 mg/kg, 50 mg/kg, or 100 mg/kg body weight of the extract at 24-hour intervals. Sexual behavior parameters (mount frequency, intromission frequency, ejaculatory latency, mount latency, intromission latency) and serum testosterone concentrations were measured on days 1, 3, and 5.
What was found
The abstract reports no raw numerical values, effect sizes, or control group measurements. Phytochemical screening identified alkaloids and saponins, with weak presence of anthraquinones and flavonoids. All doses produced reported increases in mount frequency, intromission frequency, and ejaculatory latency, along with reductions in mount latency and intromission latency (reported as P 0.05). Serum testosterone concentrations also reportedly increased across all dose groups in a dose-dependent manner.
Why it matters
This study provides early preclinical evidence that Fadogia agrestis stem extract influences rodent copulatory behaviors and increases circulating testosterone, offering a biological rationale for traditional use.
Limits
The study was conducted entirely in rats and cannot establish human efficacy, appropriate dosing, or safety. The abstract does not disclose the sample size, control group specifications, quantitative data, or exact p-values. Toxicity and long-term effects were not evaluated.
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