Peyronie's disease.
Level 5 - mechanism / opinion, no new human data
Expert consensus committee report and narrative review without systematic review methodology.
PubMed 16422991 · doi:10.1111/j.1743-6109.2004.10116.x
What was done
A committee of 10 multidisciplinary experts from six countries—convened as part of an International Consultation on sexual medicine—reviewed literature, conducted internal deliberations over two years, and held public presentations to establish consensus recommendations on the pathophysiology, diagnosis, and treatment of Peyronie's disease.
What was found
The abstract reports no quantitative metrics or statistical effect sizes. Qualitatively, the panel reported that few medical therapies demonstrate significant clinical efficacy in prospective controlled trials. For stabilized disease, surgical strategies depend on baseline erectile function and deformity characteristics: the Nesbit procedure provides deformity correction with the lowest reported rate of postoperative erectile dysfunction (ED); plaque incision and grafting is reserved for severe shortening in men with intact erectile function due to higher postoperative ED risk; and penile prosthesis implantation is indicated when significant ED coexists.
Why it matters
This report synthesized international expert opinion to outline standardized diagnostic concepts and a treatment algorithm balancing surgical deformity correction against postoperative erectile dysfunction risk.
Limits
The document reflects expert opinion and narrative review rather than a systematic review or meta-analysis. The abstract provides no quantitative data, search criteria, or formal risk-of-bias assessments. The authors explicitly note a broad deficiency of prospective, placebo-controlled clinical trials evaluating Peyronie's disease treatments.
Cited by
- supports Peyronie's disease is a condition characterized by fibrous scar tissue or damage inside the penis that causes penile curvature.