Afaghi · The American journal of clinical nutrition 2007 · randomized crossover trial · n=12

High-glycemic-index carbohydrate meals shorten sleep onset.

Cited 275 times in the scientific literature.

Level 2 - randomized trial

Randomized crossover clinical trial in humans

PubMed 17284739 · doi:10.1093/ajcn/85.2.426 · record verified 2026-08-26

What was done

Twelve healthy men (aged 18–35 years) completed a randomized crossover trial evaluating the effects of meal glycemic index (GI) and timing on sleep. Following a familiarization night, participants underwent 3 test nights spaced 1 week apart in random order. They consumed standardized isocaloric meals (3212 kJ; 90.4% carbohydrate, 8% protein, 1.6% fat) consisting of either high-GI Jasmine rice (GI = 109) or low-GI Mahatma rice (GI = 50). Three conditions were compared: high-GI meal 4 hours before bedtime, low-GI meal 4 hours before bedtime, and high-GI meal 1 hour before bedtime. Sleep onset latency and other sleep parameters were assessed.

What was found

A high-GI meal consumed 4 hours before bedtime significantly reduced mean (±SD) sleep onset latency compared with a low-GI meal consumed 4 hours before bedtime (9.0 ± 6.2 min vs. 17.5 ± 6.2 min; P = 0.009). The high-GI meal consumed 4 hours before bedtime also produced a significantly shorter sleep onset latency than the same high-GI meal consumed 1 hour before bedtime (9.0 ± 6.2 min vs. 14.6 ± 9.9 min; P = 0.01). No effects on other sleep variables were observed.

Why it matters

The study shows that manipulating dietary carbohydrate glycemic index and meal timing can meaningfully reduce sleep onset latency in healthy individuals.

Limits

The sample size was very small (n = 12) and restricted strictly to healthy young men, limiting generalizability to women, older populations, and individuals with clinical sleep disturbance. The trial only tested acute single-meal interventions rather than long-term dietary patterns.

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