De Souza · Fertility and sterility 2007 · Observational cross-sectional study · n=?

Severity of energy-related menstrual disturbances increases in proportion to indices of energy conservation in exercising women.

Cited 141 times in the scientific literature.

Level 4 - case-series / case-control

Observational cross-sectional study examining metabolic parameters across menstrual status categories

PubMed 17418159 · doi:10.1016/j.fertnstert.2006.11.171 · record verified 2026-08-26

What was done

The study evaluated markers of energy conservation, specifically resting energy expenditure and metabolic hormones, across a spectrum of menstrual disturbances (including luteal-phase defects, anovulation, and amenorrhea) in exercising women.

What was found

The abstract reports no numerical values, sample sizes, effect sizes, or statistical metrics. It qualitatively states that alterations in resting energy expenditure and metabolic hormones increased in magnitude across the continuum of worsening menstrual disturbance severity.

Why it matters

These findings suggest that clinical menstrual disorders in exercising women exist on a continuum driven by energy availability, where even subtle energetic deficits can trigger detectable reproductive dysfunction.

Limits

The abstract omits essential details, including sample size, specific hormones measured, patient selection criteria, exact diagnostic definitions, and all quantitative data (means, standard deviations, or p-values).

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