Boback · Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2007 · controlled animal feeding experiment · n=?

Cooking and grinding reduces the cost of meat digestion.

Cited 102 times in the scientific literature.

Level 5 - mechanism / opinion, no new human data

Animal physiological laboratory experiment (non-human model).

PubMed 17827047 · doi:10.1016/j.cbpa.2007.08.014 · record verified 2026-08-27

What was done

Burmese pythons (Python molurus) were fed one of four experimental beef diets weighing 25% of body mass: intact raw beef, intact cooked beef, ground raw beef, or ground cooked beef. Researchers measured pre-feeding and postprandial oxygen consumption rates up to 14 days following feeding to calculate specific dynamic action (SDA), representing the metabolic cost of digestion, absorption, and assimilation.

What was found

Postprandial peak oxygen consumption, peak scope, and total SDA differed significantly among treatments. Cooking decreased SDA by 12.7%, grinding decreased SDA by 12.4%, and combined cooking and grinding decreased SDA additively by 23.4% compared to intact raw meat.

Why it matters

Provides experimental evidence that thermal and mechanical processing reduces the metabolic cost of digestion, supporting the hypothesis that cooking increased net energy gain during human evolution.

Limits

The abstract does not state the number of animals used (n). Findings are from an ectothermic reptile model (Burmese python) consuming large infrequent meals, which limits direct extrapolation to human digestion.

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