Gillberg · Sleep 1991 · within-subject repeated-measures experimental study · n=8

The dynamics of the first sleep cycle.

Cited 36 times in the scientific literature.

Level 3 - non-randomized controlled study

Within-subject experimental physiological study with manipulated sleep deprivation conditions

PubMed 1866528 · record verified 2026-08-29

What was done

Eight subjects completed an experimental protocol evaluating sleep stages and electroencephalographic (EEG) power density during the first (and, when present, second) sleep cycles. Participants underwent four sleep deprivation conditions involving 8, 4, 2, or 0 hours of progressively postponed nighttime sleep (started at 2300, 0300, 0500, or 1100 hr), each followed by daytime sleep starting at 1100 hr. Measures included slow-wave energy (SWE), slow-wave activity (SWA), slow-wave sleep (SWS) latency, and SWS duration across cycle components.

What was found

No numerical values, p-values, or effect sizes were reported in the abstract. Reported directional findings: - Duration of the first sleep cycle showed no significant changes across conditions. - SWE and SWA during daytime sleeps (1100 hr) increased with greater prior sleep loss across entire cycles, NREM periods, and SWS periods. - SWS latency decreased markedly and SWS duration increased markedly with prior wakefulness. - After 28 hr of continuous waking, SWA during SWS increased markedly, accompanied by a spillover of SWA into the second sleep cycle.

Why it matters

This study provides evidence that homeostatic sleep pressure modulates slow-wave intensity and duration without altering the baseline period of the first sleep cycle, suggesting an upper limit to slow-wave accommodation prior to rapid eye movement (REM) sleep onset.

Limits

The study had a very small sample size (n = 8) with no participant demographics (age, sex, health status) provided in the abstract. The abstract lacks quantitative data, variance measures, and statistical test values. Potential confounding by circadian phase shifts during daytime recovery sleep was not detailed.

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