Effect of food on the pharmacokinetic profile of trans-resveratrol.
Level 2 - randomized trial
Randomized crossover trial in healthy human volunteers
PubMed 19000554 · doi:10.5414/cpp46564
What was done
In a single-center, open-label, randomized 2-way crossover study, 24 healthy participants were given a single oral dose of 400 mg trans-resveratrol under two conditions: following an 8-hour fast or after a standard high-fat meal. Treatment periods were separated by a washout period of at least 7 days. Plasma pharmacokinetic parameters, including peak concentration (Cmax), time to peak concentration (tmax), and area under the curve (AUC0-inf), were measured.
What was found
Pharmacokinetic parameters demonstrated high interindividual variability. Mean ± SD Cmax was 42.2 ± 36.6 ng/ml in fed conditions compared to 47.3 ± 30.0 ng/ml in fasting conditions. Median tmax was delayed with food to 2.0 h versus 0.5 h when fasting (p < 0.0001). The fed/fasting geometric mean ratio (90% CI) was 79.4% (53.8% to 117.0%) for Cmax and 106.0% (86.8% to 128.0%) for AUC0-inf. The 90% confidence intervals for both fell outside the standard 80% to 125% bioequivalence window, though total AUC was close.
Why it matters
This indicates that taking trans-resveratrol with a high-fat meal slows the rate of absorption without substantially reducing total systemic exposure, allowing flexibility regarding meal timing in clinical evaluations.
Limits
The study had a small sample size (n = 24), included only healthy volunteers, was open-label, and tested only a single 400 mg dose with a high-fat meal. It did not assess multiple-dose accumulation, other meal compositions, metabolite levels, or clinical outcomes. High interindividual variability led to wide confidence intervals.
Cited by
- contradicts Consuming resveratrol with fat increases its absorption and bloodstream levels 5- to 10-fold compared to taking dry powder alone.