The Randle cycle revisited: a new head for an old hat.
Level 5 - mechanism / opinion, no new human data
Narrative review describing biochemical mechanisms without original empirical data or systematic search
PubMed 19531645 · doi:10.1152/ajpendo.00093.2009
What was done
This is a narrative review examining the biochemical mechanisms underlying the Randle (glucose-fatty acid) cycle. The authors synthesized short- and long-term regulatory pathways controlling glucose and fatty acid utilization across cytoplasmic and mitochondrial compartments in mammalian muscle and liver under physiological and pathophysiological states.
What was found
The abstract reports no empirical numbers or quantitative findings. It describes conceptual extensions to the classic model of fatty acid-mediated inhibition of glucose oxidation, identifying regulatory layers that include allosteric control, reversible phosphorylation, and transcriptional regulation of metabolic enzymes.
Why it matters
This review integrates modern biochemical signaling pathways into the classical glucose-fatty acid cycle framework. It provides a theoretical basis for understanding metabolic flexibility and fuel selection in health and disease.
Limits
As a non-systematic narrative review, the paper provides no original empirical data, quantitative synthesis, or detailed search criteria. The abstract does not specify the underlying experimental models or sample sizes.
Cited by
- context Mitochondria have a preference for utilizing fat as fuel over glucose.