Gastric exocrine and endocrine secretion.
Level 5 - mechanism / opinion, no new human data
Narrative review of physiological mechanisms without systematic search methodology or original clinical data
PubMed 19726980 · doi:10.1097/MOG.0b013e328331b62a
What was done
This narrative review summarizes literature from the preceding year regarding the regulation, physiology, and measurement of gastric exocrine and endocrine secretions.
What was found
No quantitative data, effect estimates, or sample sizes were reported in the abstract. The review summarizes key physiological mechanisms: parietal cells secrete hydrochloric acid and various peptides (transforming growth factor-alpha, amphiregulin, heparin-binding epidermal growth factor-like growth factor, and sonic hedgehog); acid secretion is stimulated by gastrin, histamine, acetylcholine, ghrelin, and orexin, and inhibited by somatostatin, nitric oxide, and dopamine; cytoskeletal proteins ezrin and moesin participate in acid and pepsinogen secretion, respectively; and while Helicobacter pylori is associated with duodenal ulcer disease, most infected individuals produce lower-than-normal amounts of acid.
Why it matters
The summary provides an overview of regulatory pathways governing gastric acid and enzyme secretion to contextualize both acid-excess disorders and hyposecretory states.
Limits
The abstract describes a non-systematic narrative review without specified search criteria, inclusion standards, study counts, or quantitative data synthesis. Details regarding experimental models (human versus animal or cell culture) are not specified.
Cited by
- contradicts Ghrelin is secreted by oxyntic cells in the stomach.