Sirtuin/Sir2 phylogeny, evolutionary considerations and structural conservation.
Level 5 - mechanism / opinion, no new human data
Level 5 by design analogy (evolutionary phylogenetic review and computational sequence analysis without clinical data).
PubMed 19936627 · doi:10.1007/s10059-009-0169-x
What was done
The authors conducted a phylogenetic analysis and structural conservation assessment of the sirtuin (Sir2-like NAD+-dependent deacetylase) family across organisms from bacteria to mammals.
What was found
The abstract reports no numerical data or statistical effect sizes. The authors report that sirtuins classify into more than a dozen classes and subclasses. The seven sirtuins found in humans and other vertebrates (SIRT1–SIRT7) originated early in animal evolution, with amino acid conservation localized predominantly around the shared catalytic center.
Why it matters
This work outlines the evolutionary divergence and classification of SIRT1 through SIRT7, illustrating the ancient origin and structural conservation of sirtuin catalytic domains.
Limits
The abstract provides no specific quantitative details, such as the exact number of species or protein sequences evaluated, alignment methods, or phylogenetic branch support values. As a descriptive evolutionary analysis and review, it provides no clinical or direct experimental data.
Cited by
- supports Humans have seven sirtuin enzymes (SIRT1 through SIRT7), whereas yeast have five sirtuins.