Grimbos · Behavioral neuroscience 2010 · meta-analysis of observational studies · n=5828

Sexual orientation and the second to fourth finger length ratio: a meta-analysis in men and women.

Cited 259 times in the scientific literature.

Level 3 - non-randomized controlled study

Meta-analysis of observational/cross-sectional studies (graded by design analogy, not clinical CEBM)

PubMed 20364887 · doi:10.1037/a0018764 · record verified 2026-08-26

What was done

The authors performed a meta-analysis assessing the relationship between digit ratio (2D:4D) and sexual orientation across 18 independent male samples (1,618 heterosexual men, 1,503 gay men) and 16 independent female samples (1,693 heterosexual women, 1,014 lesbians), evaluating both hands and examining ethnicity as a moderator.

What was found

Heterosexual women had higher (more feminine) left- and right-hand 2D:4D than lesbians, whereas no difference was observed between heterosexual and gay men. Moderator analyses indicated that ethnicity accounted for some between-study variation in men. No numerical effect sizes, test statistics, or confidence intervals were reported in the abstract.

Why it matters

This adds evidence that prenatal sex hormone signaling may influence sexual orientation in women, while highlighting that the relationship in men is more complex and varies by ethnic background.

Limits

The abstract reports no numerical effect sizes or confidence intervals. Digit ratio is an indirect proxy for prenatal androgen exposure rather than a direct hormonal measurement, and substantial between-study variation was observed among men.

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