Vitamin D and the immune system: new perspectives on an old theme.
Level 5 - mechanism / opinion, no new human data
Narrative review synthesizing mechanistic pathways and expert perspective without original data or systematic review methods
PubMed 20511058 · doi:10.1016/j.ecl.2010.02.010
What was done
This is a narrative review summarizing literature on the interaction between vitamin D and the immune system, specifically the local autocrine and paracrine conversion of 25-hydroxyvitamin D3 to active 1,25-dihydroxyvitamin D3 in innate and adaptive immune responses.
What was found
The abstract reports no numerical data or quantitative outcomes. It describes that 1,25-dihydroxyvitamin D3 contributes to normal innate and adaptive immune function and that deficiency in vitamin D status may impair response to infection or predispose to autoimmunity.
Why it matters
It highlights that immune effects of vitamin D rely on localized tissue synthesis rather than solely endocrine actions, linking widespread vitamin D insufficiency to potential immune dysfunction.
Limits
This is a narrative review with no original clinical data, predefined search methodology, or quantitative synthesis reported in the abstract. No sample size is applicable.
Cited by
- supports Circulating 25-hydroxyvitamin D is converted into active 1,25-dihydroxyvitamin D not only in the kidneys but also locally within white blood cells.