Craig · Brain structure & function 2010 · narrative review · n=?

The sentient self.

Cited 610 times in the scientific literature.

Level 5 - mechanism / opinion, no new human data

Narrative review and theoretical neuroanatomical model without original empirical data or systematic search

PubMed 20512381 · doi:10.1007/s00429-010-0248-y · record verified 2026-08-26

What was done

This narrative review synthesizes neuroanatomical evidence regarding the progression of integrative representations of affective bodily feelings in the brain. It examines somatotopic organization in the primary interoceptive sensory cortex, the anatomical and functional organization of the mid-insula and anterior insula, and introduces a theoretical cinemascopic model of subjective awareness.

What was found

The abstract reports no numerical data or quantitative outcomes. It presents a neuroanatomical progression wherein somatic affective inputs ascend to primary interoceptive cortex and culminate in an integrative representation across the bilateral anterior insulae, theorized to form the basis of the sentient self.

Why it matters

The paper outlines an influential neuroanatomical framework proposing the anterior insula as the primary cortical substrate for subjective feeling states and conscious self-awareness.

Limits

As a theoretical synthesis and narrative review, it presents no new empirical measurements or quantitative results. Generalizability and causal claims cannot be evaluated directly from this conceptual model.

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