Two susceptible diabetogenic variants near/in MTNR1B are associated with fasting plasma glucose in a Han Chinese cohort.
Level 4 - case-series / case-control
Case-control genetic association study in humans
PubMed 20536959 · doi:10.1111/j.1464-5491.2010.02975.x
What was done
Researchers evaluated two single-nucleotide polymorphisms (rs1387153 and rs10830963) near/in the MTNR1B gene in 1,912 unrelated Han Chinese patients with type 2 diabetes and 2,041 healthy controls. Associations with type 2 diabetes were calculated using logistic regression adjusting for age, sex, and body mass index, while associations with fasting plasma glucose (FPG) in healthy controls were tested using multiple linear regression.
What was found
Both rs1387153 and rs10830963 were significantly associated with FPG levels in healthy controls (P = 0.003 and P = 0.002, respectively). The G allele of rs10830963 was associated with higher type 2 diabetes risk (odds ratio 1.12, 95% CI 1.02–1.23, P = 0.024). Linkage disequilibrium between the two variants was high (r² = 0.66), comparable to European populations.
Why it matters
This study replicates in a Han Chinese cohort the MTNR1B genetic associations with fasting glucose and type 2 diabetes risk previously identified in European populations, supporting a shared genetic architecture across distinct ethnic backgrounds.
Limits
The abstract does not provide the absolute effect sizes (beta coefficients) for fasting glucose changes. The study is limited to a Han Chinese population, relies on a cross-sectional case-control design, and did not assess functional mechanisms or longitudinal progression from elevated fasting glucose to diabetes.
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