Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters.
Level 5 - mechanism / opinion, no new human data
Narrative review of mechanistic and preclinical research without systematic methodology or primary human trial data.
PubMed 20599443 · doi:10.1016/j.pharmthera.2010.06.003
What was done
This is a narrative review summarizing literature published since the cloning of ACE2 in 2000 regarding its biological functions across physiology and disease.
What was found
The abstract reports no quantitative data or numerical outcomes. It summarizes three primary functions of ACE2: (1) acting as a negative regulator of the renin-angiotensin system by degrading angiotensin II to protect cardiovascular and other organ systems; (2) serving as the essential receptor for SARS coronavirus, where its downregulation contributes to acute lung failure; and (3) associating with amino acid transporters to facilitate amino acid absorption in the kidney and gut.
Why it matters
This review synthesizes the multifaceted roles of ACE2 across cardiovascular control, coronavirus entry and pathogenesis, and nutrient transport.
Limits
The abstract describes a non-systematic narrative review without primary empirical data, human clinical trial metrics, or reported search methodology. No quantitative effect sizes are provided.
Cited by
- contradicts ACE2 is normally a water channel in cells, especially in the lungs.