Clark · Trends in cognitive sciences 2010 · narrative review · n=?

Cognitive theory and therapy of anxiety and depression: convergence with neurobiological findings.

Cited 625 times in the scientific literature.

Level 5 - mechanism / opinion, no new human data

Narrative review and theoretical framework without systematic methodology or original empirical data.

PubMed 20655801 · doi:10.1016/j.tics.2010.06.007 · record verified 2026-08-26

What was done

This review proposed a modified cognitive neurophysiological model integrating Aaron T. Beck's cognitive formulation of anxiety and depression with cognitive neuroscience findings, discussing neural mediational mechanisms of cognitive therapy.

What was found

The abstract reports no numerical data or quantitative outcomes. It conceptually relates cognitive therapy efficacy to decreased activation in subcortical areas generating negative emotion (amygdalohippocampal regions) and increased activation in higher-order frontal regions involved in cognitive control.

Why it matters

It provides a mechanistic neurobiological framework mapping cognitive therapy techniques onto fronto-subcortical brain networks involved in emotion regulation.

Limits

This is a narrative review presenting a theoretical model rather than a systematic review or empirical study. No sample sizes, study counts, or quantitative effect sizes are reported in the abstract.

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