Coghill · Headache 2010 · narrative review · n=?

Individual differences in the subjective experience of pain: new insights into mechanisms and models.

Cited 206 times in the scientific literature.

Level 5 - mechanism / opinion, no new human data

Narrative review/commentary without new human data or systematic methodology

PubMed 20958300 · doi:10.1111/j.1526-4610.2010.01763.x · record verified 2026-08-29

What was done

This paper provides a narrative discussion on the mechanisms underlying individual differences in pain sensitivity, focusing on the integration of psychophysical testing and functional brain imaging techniques to develop individualized models for pain management.

What was found

The abstract provides no empirical data, sample sizes, or quantitative results. It broadly describes how combining psychophysics with functional neuroimaging has advanced the understanding of neural mechanisms involved in differential pain experiences following similar sensory inputs.

Why it matters

Understanding the neural and psychological basis of pain variability provides a conceptual framework for developing individualized pain assessment and targeted treatments.

Limits

The abstract describes a narrative review rather than an empirical study or systematic review. No primary experimental data, participant details, or quantitative measures are provided.

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