Reed · Progress in molecular biology and translational science 2010 · narrative review · n=?

Genetics of taste and smell: poisons and pleasures.

Cited 257 times in the scientific literature.

Level 5 - mechanism / opinion, no new human data

Narrative review without systematic search or primary data synthesis

PubMed 21036327 · doi:10.1016/B978-0-12-375003-7.00008-X · record verified 2026-08-27

What was done

This paper reviews literature from human and animal genetic studies on how taste and smell receptors mediate defensive eating (avoidance of bitter toxins and spoiled odors) and hedonic consumption of high-fat, high-sugar foods.

What was found

The abstract reports no numerical data. It summarizes that genetic variations between individuals influence both the sensitivity to bitterness and malodors and the individual liking of sugar and fat.

Why it matters

Understanding the genetic basis of individual chemosensory variation could inform personalized dietary strategies to address obesity and related metabolic diseases.

Limits

As a narrative review, the abstract provides no quantitative effect sizes, search methodology, sample sizes, or identification of specific causal genetic variants.

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