Orthostatic tremor - a review.
Level 5 - mechanism / opinion, no new human data
Narrative review without systematic search or human trial data
PubMed 21496602 · doi:10.1016/B978-0-444-52014-2.00035-5
What was done
This narrative review summarizes the clinical characteristics, neurophysiological criteria, pathophysiology, and treatment options for orthostatic tremor.
What was found
The abstract reports no numerical outcome data. Orthostatic tremor typically begins in the sixth decade and is diagnosed by polygraphic recording of synchronous 13-18 Hz leg tremor. Lower-frequency tremors in other body parts may represent subharmonics. While most cases are idiopathic, associations with Parkinson's disease are described. Pharmacological response is often disappointing, though clonazepam, gabapentin, and dopaminergic agents are utilized.
Why it matters
It outlines diagnostic electrophysiology and pharmacological strategies for a rare, disabling movement disorder.
Limits
As a narrative review, it lacks a systematic literature search, risk-of-bias assessment, or meta-analytic data. No sample sizes, effect sizes, or comparative efficacy metrics are reported in the abstract.
Cited by
- supports Orthostatic tremor presents as rapid leg shaking when standing still that improves or resolves when walking or sitting.