Puterman · Psychosomatic medicine 2011 · cross-sectional laboratory challenge study · n=46

Physical activity moderates effects of stressor-induced rumination on cortisol reactivity.

Cited 104 times in the scientific literature.

Level 4 - case-series / case-control

Cross-sectional laboratory challenge study evaluating observational lifestyle differences

PubMed 21873586 · doi:10.1097/PSY.0b013e318229e1e0 · record verified 2026-08-30

What was done

Forty-six postmenopausal women completed the Trier Social Stress Test with repeated salivary cortisol sampling. Twenty-five minutes after the stressor ended, participants reported their level of stress-induced rumination. The researchers evaluated whether maintaining a physically active lifestyle moderated the relationship between rumination and log-transformed cortisol reactivity and recovery trajectories.

What was found

Physical activity moderated the initial rate (B = -0.10, standard error = 0.04, p < .05) and curvature (B = -0.03, standard error = 0.01, p = .06) of the relationship between rumination and log-transformed cortisol trajectories. Sedentary participants with higher rumination showed a more rapid initial cortisol rise (0.26 vs. 0.21, p < .001), a later peak (56 vs. 39 minutes), and delayed recovery (curvature: -0.07 vs. -0.08, p < .001) compared with sedentary participants with lower rumination. In active participants, cortisol trajectories remained equivalent regardless of rumination level.

Why it matters

This study provides physiological evidence that regular physical activity may buffer against prolonged hypothalamic-pituitary-adrenal axis activation provoked by acute psychological rumination.

Limits

The sample was small (n = 46) and limited entirely to postmenopausal women, restricting generalizability. Physical activity was an observational lifestyle variable rather than a randomized intervention, and rumination was assessed via self-report.

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